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tree spot compound profile visualization tool  (DiscoverX corporation)

 
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    Structured Review

    DiscoverX corporation tree spot compound profile visualization tool
    Selective antiproliferative effect <t>of</t> <t>TAE684</t> in ALK-positive NSCLC. The kinase inhibition profile by TAE684 (IC 50 , mapped by <t>TREE</t> spot ) as well as its 2D and 3D molecular structures (adapted from PubChem) are shown ( a ). Cell proliferation was assessed by counting viable cells 72 post treatment with a cell-permeant DNA-binding fluorescent dye (CyQuant-Direct) ( b ). Alternatively, cell proliferation was monitored longitudinally by live microscopy and the confluence levels as well as representative photomicrographs are presented ( c and d ). TAE684 potently inhibited cell proliferation in ALK-positive H3122 NSCLC but was less or not effective in A549 and LLC cells, respectively. Bars represent mean ± SD. TK: tyrosine kinase; Ctrl: control
    Tree Spot Compound Profile Visualization Tool, supplied by DiscoverX corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/tree+spot+compound+profile+visualization+tool/pmc05756447-75-16-24?v=DiscoverX+corporation
    Average 90 stars, based on 1 article reviews
    tree spot compound profile visualization tool - by Bioz Stars, 2026-06
    90/100 stars

    Images

    1) Product Images from "Oncogene addiction and radiation oncology: effect of radiotherapy with photons and carbon ions in ALK-EML4 translocated NSCLC"

    Article Title: Oncogene addiction and radiation oncology: effect of radiotherapy with photons and carbon ions in ALK-EML4 translocated NSCLC

    Journal: Radiation Oncology (London, England)

    doi: 10.1186/s13014-017-0947-0

    Selective antiproliferative effect of TAE684 in ALK-positive NSCLC. The kinase inhibition profile by TAE684 (IC 50 , mapped by TREE spot ) as well as its 2D and 3D molecular structures (adapted from PubChem) are shown ( a ). Cell proliferation was assessed by counting viable cells 72 post treatment with a cell-permeant DNA-binding fluorescent dye (CyQuant-Direct) ( b ). Alternatively, cell proliferation was monitored longitudinally by live microscopy and the confluence levels as well as representative photomicrographs are presented ( c and d ). TAE684 potently inhibited cell proliferation in ALK-positive H3122 NSCLC but was less or not effective in A549 and LLC cells, respectively. Bars represent mean ± SD. TK: tyrosine kinase; Ctrl: control
    Figure Legend Snippet: Selective antiproliferative effect of TAE684 in ALK-positive NSCLC. The kinase inhibition profile by TAE684 (IC 50 , mapped by TREE spot ) as well as its 2D and 3D molecular structures (adapted from PubChem) are shown ( a ). Cell proliferation was assessed by counting viable cells 72 post treatment with a cell-permeant DNA-binding fluorescent dye (CyQuant-Direct) ( b ). Alternatively, cell proliferation was monitored longitudinally by live microscopy and the confluence levels as well as representative photomicrographs are presented ( c and d ). TAE684 potently inhibited cell proliferation in ALK-positive H3122 NSCLC but was less or not effective in A549 and LLC cells, respectively. Bars represent mean ± SD. TK: tyrosine kinase; Ctrl: control

    Techniques Used: Inhibition, Binding Assay, CyQUANT Assay, Microscopy, Control



    Similar Products

    tree spot compound profile visualization tool  (DiscoverX corporation)
    90
    DiscoverX corporation tree spot compound profile visualization tool
    Selective antiproliferative effect <t>of</t> <t>TAE684</t> in ALK-positive NSCLC. The kinase inhibition profile by TAE684 (IC 50 , mapped by <t>TREE</t> spot ) as well as its 2D and 3D molecular structures (adapted from PubChem) are shown ( a ). Cell proliferation was assessed by counting viable cells 72 post treatment with a cell-permeant DNA-binding fluorescent dye (CyQuant-Direct) ( b ). Alternatively, cell proliferation was monitored longitudinally by live microscopy and the confluence levels as well as representative photomicrographs are presented ( c and d ). TAE684 potently inhibited cell proliferation in ALK-positive H3122 NSCLC but was less or not effective in A549 and LLC cells, respectively. Bars represent mean ± SD. TK: tyrosine kinase; Ctrl: control
    Tree Spot Compound Profile Visualization Tool, supplied by DiscoverX corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/tree+spot+compound+profile+visualization+tool/pmc05756447-75-16-24?v=DiscoverX+corporation
    Average 90 stars, based on 1 article reviews
    tree spot compound profile visualization tool - by Bioz Stars, 2026-06
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Selective antiproliferative effect of TAE684 in ALK-positive NSCLC. The kinase inhibition profile by TAE684 (IC 50 , mapped by TREE spot ) as well as its 2D and 3D molecular structures (adapted from PubChem) are shown ( a ). Cell proliferation was assessed by counting viable cells 72 post treatment with a cell-permeant DNA-binding fluorescent dye (CyQuant-Direct) ( b ). Alternatively, cell proliferation was monitored longitudinally by live microscopy and the confluence levels as well as representative photomicrographs are presented ( c and d ). TAE684 potently inhibited cell proliferation in ALK-positive H3122 NSCLC but was less or not effective in A549 and LLC cells, respectively. Bars represent mean ± SD. TK: tyrosine kinase; Ctrl: control

    Journal: Radiation Oncology (London, England)

    Article Title: Oncogene addiction and radiation oncology: effect of radiotherapy with photons and carbon ions in ALK-EML4 translocated NSCLC

    doi: 10.1186/s13014-017-0947-0

    Figure Lengend Snippet: Selective antiproliferative effect of TAE684 in ALK-positive NSCLC. The kinase inhibition profile by TAE684 (IC 50 , mapped by TREE spot ) as well as its 2D and 3D molecular structures (adapted from PubChem) are shown ( a ). Cell proliferation was assessed by counting viable cells 72 post treatment with a cell-permeant DNA-binding fluorescent dye (CyQuant-Direct) ( b ). Alternatively, cell proliferation was monitored longitudinally by live microscopy and the confluence levels as well as representative photomicrographs are presented ( c and d ). TAE684 potently inhibited cell proliferation in ALK-positive H3122 NSCLC but was less or not effective in A549 and LLC cells, respectively. Bars represent mean ± SD. TK: tyrosine kinase; Ctrl: control

    Article Snippet: The kinase inhibition spectrum (IC 50 ) of TAE684 was visualized (Fig. ) and mapped by TREE spot TM Compound Profile Visualization Tool ( http://www.discoverx.com/services/drug-discovery-development-services/treespot-data-analysis ) [ ].

    Techniques: Inhibition, Binding Assay, CyQUANT Assay, Microscopy, Control